| Study | Reason for exclusion |
|---|---|
| Amar 2003 | Wrong participant group - a randomised controlled trial examining the usefulness of antifibrinolytic therapy in patients with non-haematological malignancy undergoing major orthopaedic surgery |
| Antun 2013 | Not an RCT - an observational study of thrombocytopenic patients who received EACA for the prevention of bleeding |
| Bartholomew 1989 | Not an RCT - a non-randomised controlled trial on the control of bleeding in people with immune and non-immune thrombocytopenia with aminocaproic acid |
| Bates 2011 | Review |
| Bedirhan 2001 | Wrong intervention - a randomised controlled trial investigating the use of aprotinin in postoperative bleeding and the need for blood products in thoracic surgery |
| Ben-Bassat 1990 | Not an RCT - non-randomised and non-controlled study of TXA therapy in AML |
| Breen 2012 | Review |
| Brown 2002 | Review |
| Byams 2007 | Wrong participant group - a cross-over study evaluating the use of desmopressin and TXA in women with menorrhagia |
| Cattan 1963 | Not an RCT - non-randomised study of EACA in people with thrombocytopenia |
| Celebi 2006 | Wrong participant group - a randomised, double-blind prospective study that examined the role of antifibrinolytic agents in gynaecologic cancer surgery |
| Chakrabarti 1998 | Not an RCT - non-randomised and non-controlled trial of EACA in people with acute leukaemia |
| Dean 1997 | Not an RCT - non-randomised and non-controlled trial of EACA and TXA for cancer-associated bleeding problems |
| Fossa 1978 | Not an RCT - non-randomised, controlled pilot study on the effect of TXA in patients being treated for various advanced malignancies |
| Gardner 1980 | Not an RCT - a series of cases of patients with amegakaryocytic thrombocytopenia treated with EACA to control bleeding |
| Garewal 1985 | Not an RCT - non-randomised and non-controlled trial of EACA for the control of bleeding in thrombocytopenic people |
| Jeserschek 2003 | Wrong intervention - a randomised controlled trial examining the role of high-dose aprotinin in the reduction of bleeding in major orthopaedic surgery |
| Kalmadi 2006 | Not an RCT - retrospective study of the effect of EACA on transfusion requirements in patients with thrombocytopenic haemorrhage |
| Katzel 1998 | Wrong intervention - a prospective, controlled, double-blind pilot study examining the role of aprotinin during thoracic surgery for malignant lung disease |
| Levy 2005 | Review |
| Marti-Carvajal 2011 | Review |
| McConnell 2011 | Wrong participant group - a randomised controlled trial examining the reduction of blood loss in primary hip arthoplasty with TXA fibrin spray |
| McConnell 2012 | Wrong participant group - a randomised controlled trial examining the reduction of blood loss in primary knee arthoplasty with TXA fibrin spray |
| Mevio 1983 | Wrong participant group - a double-blind study examining the role of tranexamic acid in the prevention of radiomucositis in head and neck cancer patients submitted for radiotherapy |
| Movafegh 2011 | Wrong participant group - a randomised, double-blind study examining the effect of intravenous tranexamic acid on blood loss during and after caesarian delivery |
| NCT01980355 | Wrong participant group - patients undergoing major oncological surgery for standard of care purposes (to include: liver resections, radical cholecystectomy, pancreaticoduodenectomy [Whipple procedure], oesophagectomy, gastrectomy, colectomy, and debulking with hyperthermic intraperitoneal chemotherapy, prostatectomies, nephrectomies, and partial nephrectomies) |
| Rathi 2015 | Not an RCT - non-randomised study of use of EACA in people with diffuse alveolar haemorrhage |
| Rickles 2007 | Review |
| Sanz 2010 | Not an RCT - non-randomised with historical control evaluating the use of TXA in people with promyelocytic leukaemia |
| Schwartz 1986 | Not an RCT - a non-randomised, non-controlled trial of the effect of EACA in people with APML and acquired alpha-2-plasmin inhibitor deficiency |
| Wassenaar 2008 | Not an RCT - a retrospective study of the use of EACA in people with APML and acquired alpha-2-plasmin inhibitor deficiency |
| Yang 2001 | Wrong participant group - a randomised, comparative trial examining the efficacy of TXA in reducing postpartum blood loss in primigravid women |
AML: acute myeloid leukaemia
APML: acute promyelocytic leukaemia
EACA: epsilon aminocaproic acid
RCT: randomised controlled trial
TXA: tranexamic acid