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. Author manuscript; available in PMC: 2016 Dec 6.
Published in final edited form as: Mol Ther. 2016 Jun 6;24(8):1369–1377. doi: 10.1038/mt.2016.110

Figure 5. The effect of residue location on transposition rate, in the two regions of the protein.

Figure 5

(median, box: 25%-75%, whiskers: 10%-90%). A) In the HTH-region, mutants of sectors, conserved or buried residues are not significantly different from the remaining mutants (p > 0.05 for all comparisons, Mann-Whitney U tests). B) In the DDE domain the differences are highly significant (p < 0.05 for all comparisons, Mann-Whitney U tests), even after correcting for the different effects of free energy of folding (C). Note that in the DDE domain 50% of mutants of “other” residues are characterized with higher activity than the wild type SB.