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. Author manuscript; available in PMC: 2016 Dec 6.
Published in final edited form as: Mol Ther. 2016 Jun 6;24(8):1369–1377. doi: 10.1038/mt.2016.110

Figure 6. The effect of DNA-protein and protein-protein interactions on transposition rate.

Figure 6

When outliers are excluded, mutants of residues interacting with DNA (“DNA”) and the other SB chain (“PPI”) have significantly lower transposition rates (p< 0.05, Mann-Whitney U test) than other residues located at the surface (RSA > 0.1). Surprisingly, 12 of the 14 hyperactive mutants (outliers, 300+% activity) are also located in the protein surface, and none in the DNA binding regions, suggesting that the modification of protein-protein interactions might be responsible for their dramatically increased activity. (Outliers with identical transposition rates were shifted by 10%, for visibility)