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A) Problems encountered with unprotected Rho in peptide chemistry. B) Synthesis of N,N'-Boc-protected Rho. a) Ac2O, H2SO4, 120°C (99%) ; b) EtOH, EDC, CH2Cl2 (94%); c) NaOEt, EtOH; d) Tf2O, pyridine, CH2Cl2 (57%); e) BocNH2, Pd2dba3, Xantphos, Cs2CO3, dioxane, 100ºC (82%); f) NaOH, THF(95%).
