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Example of colour coded SPR signals obtained by chemical microarray screening of hTau2N4Rwt under optimized conditions against: (A) a fragment library of 3,000 fragments (out of 25,000 fragments present in the small molecule library screened) spotted in triplicates, and (B) a lead-like library combining (96×96 =9,216) motifs. Reproducibility of screening experiments for chemical microarray with (C) fragments and for (D) lead-like compounds immobilized.
