Table 5.
Percentage difference in bone outcomes by type of menopause, per 10 year difference in timing of period cessation (natural or surgical), per 10-year difference in HRT use, height, weight, smoking and adult occupation.
| Diaphysis CSA (n=508)* | Medullary CSA (n=507)* | Total vBMD (mg/cm3) (n=502)* | Trabecular vBMD (mg/cm3) (n=501)* | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| % diff | 95% CI | p-value | % diff | 95% CI | p-value | |||||||
| Hysterectomy v. natural menopause (at age 50) | 0.5 | -2.7, 3.7 | .8 | -3.1 | -11.8, 5.6 | .5 | 5.8 | 0.5, 11 | .03 | 5.8 | -0.8, 12.4 | .08 |
| Age at period cessation (per 10y) | ||||||||||||
| Ceased naturally | 0.1 | -3.4, 3.5 | >.9 | -8.5 | -17.9, 0.9 | .08 | 3.7 | -2, 9.4 | .2 | 7.1 | 0.04, 14.2 | .05 |
| Ceased surgically | -0.3 | -3.6, 3 | .8 | 0.5 | -8.4, 9.4 | .9 | 2.4 | -3, 7.8 | .4 | 1.5 | -5.2, 8.2 | .7 |
| HRT use (per 10y) | 2.3 | -0.3, 4.9 | .08 | -6.3 | -13.4, 0.8 | .08 | 2.5 | -1.8, 6.8 | .3 | 4.0 | -1.4, 9.3 | .1 |
| Height (per 1 SD) | 5.1 | 3.9, 6.2 | <.001 | 7.5 | 4.5, 10.5 | <.001 | -2.5 | -4.3, -0.7 | .008 | -4.0 | -6.3, -1.8 | .001 |
| Weight (per 1 SD) | 2.9 | 1.8, 4.1 | <.001 | 0.3 | -2.9, 3.4 | .9 | 4.2 | 2.3, 6.1 | <.001 | 5.7 | 3.3, 8 | <.001 |
| Smoking v not smoking | 1.1 | -2.7, 4.9 | .6 | 2.1 | -8.2, 12.4 | .7 | 0.7 | -5.6, 7 | .8 | -1.2 | -9, 6.7 | .8 |
| Manual v non-manual social class | -0.5 | -3.4, 2.3 | .7 | 1.6 | -6.1, 9.3 | .7 | -0.6 | -5.4, 4.1 | .8 | 0.9 | -4.9, 6.7 | .8 |
| Cortical vBMD (n=509)* | Polar SSI (n=509)* | Lumbar spine aBMD (n=635)* | Total hip aBMD (n=632)* | |||||||||
| % diff | 95% CI | p-value | % diff | 95% CI | p-value | % diff | 95% CI | p-value | % diff | 95% CI | p-value | |
| Hysterectomy v. natural menopause | 0.2 | -0.7, 1 | .7 | 2.9 | -1.8, 7.6 | .2 | 6.0 | 2.3, 9.8 | .002 | 3.7 | 0.8, 6.7 | .01 |
| Age at period cessation (per 10y) | ||||||||||||
| Ceased naturally | 0.5 | -0.4, 1.4 | .3 | 1.0 | -4.1, 6.1 | .7 | 8.8 | 4.8, 12.7 | <.001 | 5.8 | 2.6, 8.9 | <.001 |
| Ceased surgically | 0.2 | -0.7, 1.1 | .6 | -0.1 | -4.9, 4.8 | >.9 | 3.3 | -0.5, 7.1 | .09 | 1.6 | -1.4, 4.6 | .3 |
| HRT use (per 10y) | 0.9 | 0.2, 1.6 | .01 | 6.3 | 2.5, 10.2 | .001 | 3.6 | 0.5, 6.6 | .02 | 2.7 | 0.3, 5.1 | .03 |
| Height (per 1 SD) | -0.01 | -0.3, 0.3 | >.9 | 6.7 | 5.1, 8.4 | <.001 | 0.7 | -0.6, 2 | .3 | -0.4 | -1.4, 0.7 | .5 |
| Weight (per 1 SD) | 0.3 | -0.03, 0.6 | .07 | 4.5 | 2.8, 6.2 | <.001 | 6.2 | 4.9, 7.5 | <.001 | 8.1 | 7.1, 9.2 | <.001 |
| Smoking v not smoking | -0.2 | -1.3, 0.8 | .6 | 1.0 | -4.6, 6.6 | .7 | -2.2 | -6.7, 2.3 | .3 | -3.2 | -6.9, 0.4 | .09 |
| Manual v non-manual social class | -0.3 | -1.1, 0.4 | .4 | -3.2 | -7.4, 1 | .1 | -0.6 | -3.9, 2.6 | .7 | -1.1 | -3.7, 1.5 | .4 |
*
Samples exclude between 53 and 68 women with insufficient data on HRT use