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. Author manuscript; available in PMC: 2018 Jan 30.
Published in final edited form as: Mol Psychiatry. 2017 Jan 3;23(2):263–270. doi: 10.1038/mp.2016.198

Figure 2. Proportion of variance in SCDC scores explained by polygenic scores for (a) clinical ASD and (b) clinical schizophrenia.

Figure 2

Polygenic scores (PGS) were constructed in ALSPAC based on the largest publicly available samples for ASD (PGC ASD) and schizophrenia (PGC-SCZ2) as a training set, and then Z-standardised. The proportion of explained phenotypic variance in rank-transformed SCDC scores (Adjusted-R2) is displayed cross-sectionally at 8, 11, 14 and 17 years and given with respect to ASD-PGS (a) and schizophrenia-PGS (b). Nine different P-value thresholds PT for selecting risk alleles (PGS bins) in clinical samples are displayed. Starred P-values indicate the strength of the association (*P ≤ 0.05, **P ≤ 0.01 and ***P ≤ 0.001).

ALSPAC - Avon Longitudinal study of Parents and Children; ASD - Autism Spectrum Disorders; PGC-ASD - ASD collection of the PGC; PGC - Psychiatric Genomics Consortium ; PGC-SCZ2 - Samples of the second PGC mega-analysis of SCZ; PGS bin - Z-standardised polygenic scores according to threshold PT; SCDC - Social-Communication Disorder Checklist; SCZ - Schizophrenia