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(A) Effect of recombinant MDK on HUVEC network formation in 3D HUVEC monocultures as per confocal microscopy over a 4 day timeline. Quantification of the effect of recombinant MDK (B) on total network area in HUVEC monocultures on day 2; (C) on total cord length on day 2; and (D) on the number of branch points on day 2 (*p<0,05, **p<0,01, ***p<0,001, n=3 independent biological replicates, scale bars= 100 μm).
