Table 5.
Multivariable logistic regression analysis for the development of any brain metastasis and brain as the first site of relapse in the BCCA cohort.
| Odds to any Brain Mets (95% CI), (Events = 141) |
P-value | Odds to Brain as first distant site (95% CI), (Events = 46) |
P-value | |
|---|---|---|---|---|
| Tumor size | ||||
| <= 2cm (n = 375) | 1 | 1 | ||
| 2-5 cm (n = 525) | 1.13 (0.76-1.69) | 0.54 | 0.70 (0.37-1.33) | 0.28 |
| >5 cm (n= 69) | 0.39 (0·13-1·18) | 0.095 | ||
| Nodal Status | ||||
| Negative (n = 374) | 1 | 1 | ||
| Positive (n = 595) | 0.53 (0·34-0·82) | 0.005 | 0.55 (0.28 – 1.08) | 0.082 |
| Grade | ||||
| 1 or 2 (n = 336) | 1 | 1 | ||
| 3 (n = 633) | 1.2 (0·76-1·86) | 0.441 | 1.19 (0.57-2.48) | 0.65 |
| Any initial chemo | ||||
| No (n = 648) | 1 | 1 | ||
| Yes (n = 321) | 1.46 (0.92-2.30) | 0.11 | 0.36 (0.19-0.71) | 0.003 |
| Any initial hormonal | ||||
| No (n = 556) | 1 | 1 | ||
| Yes ( n = 413) | 0.79 (0.50-1.24) | 0.3 | 0.91 (0.45-1.84) | 0.79 |
| ER | ||||
| negative (n = 316) | 1 | 1 | ||
| Positive (n = 653) | 0.58 (0.37-0.91) | 0.018 | 0.58 (0.28-1.24) | 0.16 |
| HER2 | ||||
| negative (n = 783) | 1 | 1 | ||
| positive (n = 186) | 1.72 (1.08-2.73) | 0.023 | 1.88 (0.89-3.96) | 0.096 |
| αB-crystallin | ||||
| negative (n = 842) | 1 | 1 | ||
| Positive (n = 127) | 2.99 (1.83-4.89) | < 0.0001 | 3.15 (1.43-6.95) | 0.005 |