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. Author manuscript; available in PMC: 2017 Mar 9.

Published in final edited form as: Leukemia. 2016 Oct 3;31(3):573–579. doi: 10.1038/leu.2016.271

Table 1. Risk to childhood acute lymphoblastic leukemia at loci 10q26.13 and 12q23.1.

RAF: Risk Allele Frequency for rs35837782 is G and risk allele for rs4762284 is T, a. OR: Odds Ratio, b. CI: Confidence Interval.

	Case genotypes					Control genotypes
rs35837782 (10q26.13, LHPP)	RAF	AA	AG	GG	RAF	AA	AG	GG	OR^a	95% CI^b	P-value
UK GWAS	0.67	93	358	373	0.62	745	2,510	1,945	1.27	(1.14-1.41)	2.04X10^-5
German GWAS	0.67	93	365	376	0.63	268	952	804	1.19	(1.05-1.36)	0.0072
Meta									1.24	(1.14-1.34)	6.04 X 10^-7
UK replication 1	0.67	73	211	251	0.62	150	475	405	1.19	(1.03-1.39)	0.022
UK replication 2	0.67	56	265	253	0.61	167	497	391	1.33	(1.14-1.55)	0.0002
German replication	0.65	184	607	621	0.63	204	701	574	1.13	(1.02-1.26)	0.0203
Meta									1.20	(1.11-1.29)	3.66 X 10^-6
Combined meta									1.21	(1.15-1.28)	1.38X10^-11 (P_het= 0.48, I²= 0%)
rs4762284 (12q23.1, ELK3)	RAF	AA	AT	TT	RAF	AA	AT	TT	OR^a	95% CI^b	P-value
UK GWAS	0.33	373	358	94	0.30	2,578	2,160	462	1.18	(1.05-1.32)	0.0046
German GWAS	0.33	372	366	95	0.28	1,072	773	179	1.30	(1.14-1.49)	1.01X10^-4
Meta									1.23	(1.13-1.34)	2.87X10^-6
UK replication 1	0.31	258	227	52	0.30	497	408	98	1.03	(0.88-1.21)	0.6870
UK replication 2	0.34	232	287	52	0.29	534	434	85	1.30	(1.11-1.53)	0.0008
German replication	0.31	650	625	124	0.28	746	619	109	1.15	(1.02-1.29)	0.0178
Meta									1.16	(1.07-1.25)	3.85X10^-4
Combined meta									1.19	(1.12-1.26)	8.41X10^-9 (P_het= 0.17, I²= 38%)