. Author manuscript; available in PMC: 2016 Dec 10.

Published in final edited form as: ACS Infect Dis. 2016 Oct 4;2(12):945–957. doi: 10.1021/acsinfecdis.6b00144

Table 2.

Comparative kinetic analysis of DSM265 and DSM421 on a panel of P. falciparum and mammalian DHODHs.

Compd	DSM265	DSM421

DHODH	IC₅₀ (μM)
P. falciparum	0.0089¹	0.053¹
P. vivax	0.027¹	0.094¹
P. cynomolgi	0.012²	0.012 (0.011 – 0.014)
P. berghei	2.5²	5.0 (3.5 – 7.1)
Human	~ 100²	> 100
Mouse	2.3³	18 (15 – 20)
Rat	2.7³	22 (18 – 26)
Dog	16³	35 (31 – 39)
Rabbit	> 100²	> 100
Minipig	~ 100²	> 100
Monkey	~ 100²	> 100

¹data were taken from Table 1. ²data were taken from ¹⁸. ³data were taken from ⁴³. Triplicate data were collected for each concentration in the dose response curves and error in parenthesis represents the 95% confidence interval of the fit.