Nucleus accumbens [11C]carfentanil binding potentials (BPND) and [18F]fluorodopa Ki values in healthy controls (C), pathological gamblers (PG) and binge eaters (BE). Statistical significance denotes Bonferroni-corrected post-hoc tests after one-way ANOVA. ***p<0.001, **p<0.01, *p<0.05, NS = non-significant. Means of the left and right hemisphere values are presented. A. [11C]carfentanil, all subjects. B. [18F]fluorodopa, all subjects. C. [11C]carfentanil, women only. D. [18F]fluorodopa, women only. E. [11C]carfentanil, non-smokers only. F. [18F]fluorodopa, non-smokers only.