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. Author manuscript; available in PMC: 2017 Apr 18.
Published in final edited form as: Stat Methods Med Res. 2015 Aug 11;26(5):2376–2388. doi: 10.1177/0962280215597716

Figure 2.

Figure 2

Bias of the MLE versus its covariance with the overall sample size for under three different trial designs. RPW: randomized play the winner, SSR: sample size re-estimation.