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. Author manuscript; available in PMC: 2017 Jul 19.
Published in final edited form as: Oncogene. 2017 Mar 13;36(28):4025–4036. doi: 10.1038/onc.2017.43

Figure 2. Survival and weights of Cdc73+/+ and conventional Cdc73+/- knockout mice.

Figure 2

(A) Survival of Cdc73+/+ and Cdc73+/- mice (data for male and female mice combined) over 18 months. Kaplan-Meier analysis revealed significantly lower survival in Cdc73+/- mice when compared to Cdc73+/+ mice (80% versus 90%, Log-rank Mantel Cox test, P < 0.05). Moreover the reduced survival in the Cdc73+/- mice was observed from 15 months of age (*P < 0.05, Fisher’s exact test). (B) Kaplan-Meier analysis showed that Cdc73+/- males had significantly reduced survival than Cdc73+/- females (Log-rank Mantel Cox test, P < 0.005), which was observed from the age of 7 months (*P < 0.05, †P < 0.01, Fisher’s exact test). (C) Kaplan-Meier analysis showing that survival of male and female Cdc73+/+ mice was similar. Moreover, the survival of Cdc73+/+ male mice did not differ significantly (p=0.094) from that of Cdc73+/- male mice (see above). (D) Bodyweights at 18 months of age of Cdc73+/+ and Cdc73+/- mice, showing that the mean bodyweights of Cdc73+/+ and Cdc73+/- males, and of Cdc73+/+ and Cdc73+/- females were similar.