| Restrictive compared with liberal for people with haematological malignancies treated with intensive chemotherapy or radiotherapy, or both, with or without haematopoietic stem cell support | ||||||
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Patient or population: people w ith haematological malignancies treated w ith intensive chemotherapy or radiotherapy, or both, w ith or w ithout haematopoietic stem cell support Setting: Department of haematology Intervention: Restrictive Comparison: Liberal red blood cell transfusion NRS | ||||||
| Outcomes | Anticipated absolute effects* (95% CI) | Relative effect (95% CI) | No of Participants (studies) | Quality of the evidence (GRADE) | Comments | |
| Risk with liberal red blood cell transfusion RCTs | Risk with Restrictive | |||||
| All-cause mortality at 31 to 100 days |
Liberal: 1 death (46 participants) Restrictive: 1 death (38 participants) |
84 (1 study) | ⊕◯◯◯ VERY LOW1 | Mean 31 days follow -up | ||
| Quality of life - not reported | - | - | - | - | ||
| Number of participants with any bleeding - not reported | - | - | - | - | ||
| Number of participants with clinically significant bleeding |
Liberal: 8 (46 participants) Restrictive: 3 (38 participants) |
84 (1 study) | ⊕◯◯◯ VERY LOW1 | The study authors reported that there was no significant difference between the two groups | ||
| Serious infections - not reported | - | - | - | - | ||
| Length of hospital admission - not reported | - | - | - | - | ||
| Hospital readmission rate - not reported | - | - | - | - | ||
| * The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI). CI: Confidence interval; RR: Risk ratio; OR: Odds ratio; | ||||||
|
GRADE Working Group grades of evidence High quality: We are very confident that the true effect lies close to that of the estimate of the effect Moderate quality: We are moderately confident in the effect estimate: The true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low quality: Our confidence in the effect estimate is limited: The true effect may be substantially different from the estimate of the effect Very low quality: We have very little confidence in the effect estimate: The true effect is likely to be substantially different from the estimate of effect | ||||||
1
The level of evidence w as dow ngraded by 1 due to imprecision.