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. Author manuscript; available in PMC: 2017 Jun 24.
Published in final edited form as: Bioconjug Chem. 2017 May 10;28(6):1722–1733. doi: 10.1021/acs.bioconjchem.7b00182

Table 1. Octanol/Water Partition Coefficient (logD), Protein Binding, and Stability in Human Serum (PBS as Control) of 68Ga-Labeled Hybrid Imaging Agents.

[68Ga]Sulfo-Cy7-FSC-MG [68Ga]Sulfo-Cy7-FSC-RGD
Distribution coefficient logD (pH 7.4) −1.9 ± 0.17 −2.3 ± 0.16
Protein binding 1 h 75.9 ± 1.2 20.5 ± 0.7
2 h 74.1 ± 2.1 20.6 ± 0.9
4 h 73.3 ± 1.7 21.6 ± 1.1
Stability in PBS 1 h 95.1 ± 0.2 95.7 ± 0.1
2 h 94.9 ± 0.4 94.7 ± 0.6
4 h 94.4 ± 0.1 94.4 ± 0.3
Stability in serum 1 h 95.5 ± 0.6 94.9 ± 0.8
2 h 94.5 ± 0.5 94.4 ± 0.3
4 h 93.9 ± 0.5 92.6 ± 0.8