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. Author manuscript; available in PMC: 2018 Jun 15.
Published in final edited form as: Circ Res. 2018 Mar 13;122(11):1555–1564. doi: 10.1161/CIRCRESAHA.117.312174

Figure 1.

Figure 1

Discovery: The role of glycan traits on cardiovascular risk estimates was tested on 3281 samples available. Having identified traits significantly associated with CVD risk, we replicated them first, in an independent cohort, validated them in men and then investigated whether any of these associations could be exclusively explained by any of the individual factors that constitute the ACC/AHA10-year ASCVD risk estimate. The traits that remained associated were then tested for association with presence of subclinical atherosclerosis adjusting for the potential confounders. A sub-analysis was performed for the IgG glycan GP18 which is strongly negatively correlated with VLDL.