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. Author manuscript; available in PMC: 2018 Apr 9.
Published in final edited form as: Physiol Rev. 2018 Jan 1;98(1):117–214. doi: 10.1152/physrev.00008.2017

Figure 12.

Figure 12

A: Schematic of the effects of increasing glucose concentrations (indicated top) on mouse β-cell membrane potential and electrical activity, ATP/ADP ratio and whole-cell KATP channel conductance (GKATP). The dashed vertical lines separate phase I, II, III and IV (see main text). Schematic based on (112, 113). Schematic courtesy of Dr C Cha, Oxford. B-C: Bursts of β-cell action potentials recorded from a β-cell exposed to 10 mM glucose. The numbers ➊-➏ highlight different phases of β-cell electrical activity: ➊ the upstroke of the action potential; ➋ action potential repolarization; ➌ the plateau potential; ➍ the progressive decrease in action potential amplitude during the burst; ➎ burst termination; and ➏ the pacemaker depolarization between two successive bursts. See Section VIII.A.