Table 2.
Event Counts and Mortality Rates for Cause-Specific Unnatural Mortality in Prevalent Epilepsy and Comparison Cohorts
| Cause of Deatha | Clinical Practice Research Datalink | Secure Anonymised Information Linkage Databank | ||||||
|---|---|---|---|---|---|---|---|---|
| Epilepsy (n = 44 687; PY = 232 095) |
Comparison Cohort (n = 891 429; PY = 5 272 571) |
Epilepsy Cohort (n = 14 051; PY = 93 972) |
Comparison Cohort (n = 279 365; PY = 2 044 922) |
|||||
| No. | Rate/100 000 PY (95% CI) | No. | Rate/100 000 PY (95% CI) | No. | Rate/100 000 PY (95% CI) | No. | Rate/100 000 PY (95% CI) | |
| All deaths | 6599 | 2826.0 (2758.0-2895.2) | 62 903 | 1193.0 (1183.7-1202.3) | 2143 | 2280.5 (2184.9-2379.1) | 23 540 | 1151.1 (1136.5-1165.9) |
| Natural | 6406 | 2760.0 (2692.9-2828.5) | 61 127 | 1159.3 (1151.0-1168.6) | 2065 | 2197.5 (2103.7-2294.3) | 22 821 | 1116.0 (1101.6-1130.6) |
| Unnatural | 193 | 83.1 (71.8-95.8) | 1776 | 33.7 (32.1-35.3) | 78 | 83.0 (65.6-104.0) | 719 | 35.2 (32.6-37.8) |
| Accident | 134 | 57.7 (48.4-68.4) | 1279 | 24.3 (23.0-25.6) | 58 | 61.7 (46.9-79.8) | 493 | 24.1 (22.0-26.3) |
| Transport accident | 13 | 5.6 (3.0-9.6) | 225 | 4.3 (3.7-4.9) | 8 | 8.5 (3.7-16.8) | 69 | 3.4 (2.6-4.3) |
| Other accident | 93 | 40.7 (32.3-49.1) | 936 | 17.8 (16.6-18.9) | 41 | 43.6 (31.3-59.1) | 361 | 17.7 (15.9-19.6) |
| Accidental medicine poisoning | 24 | 10.3 (6.6-15.4) | 90 | 1.7 (1.4-2.1) | 8 | 8.5 (3.7-16.8) | 53 | 2.6 (1.9-3.4) |
| All accidental poisoning | 28 | 12.1 (8.0-17.4) | 118 | 2.2 (1.9-2.7) | 9 | 9.6 (4.4-18.1) | 63 | 3.1 (2.4-3.9) |
| Suicide | 47 | 20.3 (14.9-26.9) | 407 | 7.7 (7.0-8.5) | 16 | 17.0 (9.7-27.7) | 199 | 9.7 (8.4-11.1) |
| Suicide poisoning with medication | 26 | 11.2 (7.3-16.4) | 80 | 1.5 (1.2-1.9) | <5 | ND | 48 | 2.4 (1.7-3.1) |
| All suicide poisoning | 26 | 11.2 (7.3-16.4) | 100 | 1.9 (1.5-2.3) | <5 | ND | 54 | 2.6 (2.0-3.5) |
| Other suicide | 21 | 9.1 (5.6-13.8) | 307 | 5.8 (5.2-6.5) | 12 | 12.8 (6.6-22.3) | 145 | 7.1 (6.0-8.3) |
| Homicide | <5 | ND | 18 | 0.3 (0.2-0.5) | <5 | ND | 9 | 0.4 (0.2-0.8) |
| Iatrogenic | 9 | 3.9 (1.8-7.4) | 72 | 1.4 (1.1-1.7) | <5 | ND | 18 | 0.9 (0.5-13.9) |
Abbreviations: ND, not disclosed (calculated from cell counts <5; therefore could not be reported without compromising anonymity); PY, person-years.
a
Determined from the Office for National Statistics-recorded underlying cause of death as classified using International Statistical Classification of Diseases and Related Health Problems, Tenth Revision codes.