Table 2.
Origin and use of cell lines in the physiologically relevant models
| Cell line | Species | Origin | Use |
|---|---|---|---|
| 16HBE14o- | human | SV40 immortilized bronchial epithelial cells | bronchial epithelium, toxicity |
| A549 | human | lung carcinoma | alveolar epithelium, toxicity |
| BEAS-2 | human | epithelial virus transformed bronchial epithelial cells | bronchial epithelium, toxicity |
| Caco-2 | human | colorectal adenocarcinoma | intestinal epithelium, barrier function, toxicity |
| CAL27 | human | oral squamous cell carcinoma | cancer cell |
| Calu-3 | human | lung adenocarcinoma | bronchial epithelium, barrier function |
| CRL-2102 (C2BBe1) | human | clone of Caco-2 cells | enterocytes |
| EAhy926 | human | fusion of HUVEC with human pulmonary adenocarcinoma A549 | endothelium |
| Fa2N4 | human | SV 40 immortalized hepatocytes | hepatocytes |
| hAELVI | human | lentivirus immortalized alveolar epithelial cells | alveolar epithelium, barrier function |
| HeLa | human | cervical cancer | cancer cell |
| Hep3B | human | hepatocellular carcinoma | hepatocytes |
| HepaRG | human | liver progenitor cells | hepatocytes |
| HepG2 Hep2/C3a | human | hepatocellular carcinoma derived from HepG2 cells | hepatocytes |
| HK-2 | human | proximal tubule papilloma | renal tubule cells, barrier function |
| HMC-1 | human | mast cell leukaemia | mast cells |
| HPMEC-ST1.6R | human | virus transfected microvascular endothelial cells | endothelial cells |
| HT29 HT29-MTX | human | colon adenocarcinoma cells cells treated with methotrexate to induce mucus production | goblet cells |
| Huh7 | human | hepatocellular carcinoma | hepatocytes |
| ISO-HAS 1 | human | hemangiosarcoma | endothelium |
| J774.A1 | mouse | reticulum cell sarcoma | monocytes/macrophages function |
| LLC-PK1 | pig | kidney cells | renal tubule cells, barrier function |
| LS174 | human | colorectal adenocarcinoma | intestinal epithelium |
| LS513 | human | colorectal carcinoma | intestinal epithelium |
| M5076 | mouse | ovarian sarcoma | cancer cells |
| MCF-7 | human | breast adenocarcinoma | metabolization, action of transporters |
| MDCK | dog | distal renal tubules | renal tubule cells, barrier function |
| MG63 | human | osteosarcoma | osteoblasts |
| MH-S | murine | simian virus 40 transformed alveolar macrophages | alveolar macrophages |
| MLE 12 | mouse | lung epithelial cells | alveolar epithelium |
| MRC-5 | human | fetal lung fibroblasts | fibroblasts |
| NCI-H322 | human | bronchoalveolar carcinoma | alveolar epithelium, toxicity |
| NCI-H441 | human | Papillary lung adenocarcinoma | alveolar epithelium |
| NCI-H460 | human | large cell lung cancer | cancer cell |
| NIH/3T3 | mouse | embryonal fibroblasts | fibroblasts |
| NKi-2 | human | hTERT immortalized proximal tubule cells | proximal renal tubule cells |
| NRK52K | rat | kidney epithelial cells | renal tubule cells, barrier function |
| Raji B | human | Burkitt's Lymphoma | induction of M cell formation in co-culture |
| Rat-2 | rat | fetal fibroblasts | fibroblasts |
| RAW 264.7 | mouse | abelson murine leukemia virus-induced tumor | monocytes/macrophages function |
| T84 | human | colorectal carcinoma | intestinal epithelium |
| THP-1 | human | acute monocytic leukemia | monocytes/macrophages function |
| TK6 | human | hereditary spherocytosis lymphoblasts | genotoxicity testing |
| TLT | human | macrophages | macrophages |
| U937 | human | histiocytic lymphoma | monocytes/macrophages function |