Table 1. Summary of key research priorities to advance the understanding of PUI.

1.Reliable consensus-driven conceptualisation of PUI (defining main phenotypes and specifiers, related comorbidity and brain-based mechanisms) 2.Age- and culture-appropriate assessment instruments to screen, diagnose and measure the severity of different forms of PUI 3.Characterise the impacts of different forms of PUI on health and quality of life 4.Define the clinical courses of different forms of PUI 5.Reduce obstacles to timely recognition and interventions 6.Clarify the possible role of genetics and personality features in different forms of PUI 7.Consider the impact of social factors in the development of PUI 8.Generate and validate effective interventions, both to prevent PUI, and to treat its various forms once established 9.Identify biomarkers, including digital markers, to improve early detection and intervention