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1.
Reliable consensus-driven conceptualisation of PUI (defining main phenotypes and specifiers, related comorbidity and brain-based mechanisms)
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2.
Age- and culture-appropriate assessment instruments to screen, diagnose and measure the severity of different forms of PUI
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3.
Characterise the impacts of different forms of PUI on health and quality of life
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4.
Define the clinical courses of different forms of PUI
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5.
Reduce obstacles to timely recognition and interventions
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6.
Clarify the possible role of genetics and personality features in different forms of PUI
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7.
Consider the impact of social factors in the development of PUI
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8.
Generate and validate effective interventions, both to prevent PUI, and to treat its various forms once established
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9.
Identify biomarkers, including digital markers, to improve early detection and intervention