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. Author manuscript; available in PMC: 2019 May 30.
Published in final edited form as: Genet Med. 2018 Oct 3;21(4):982–986. doi: 10.1038/s41436-018-0281-4

Figure 2.

Figure 2

Rank, size and relative size have predictive power. The ROC curve for our combined dataset (discovery cohort plus replication cohorts, excluding samples with homozygosity >8% and variants within 3Mb of a telomere) demonstrates that there is positive predictive value for each of rank, size and relative size, with the highest predictive value coming when these are combined.