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. Author manuscript; available in PMC: 2019 Feb 15.
Published in final edited form as: Pain. 2019 Feb;160(2):463–485. doi: 10.1097/j.pain.0000000000001416

Figure 4.

Figure 4

Expression patterns of LncRNAs in Human IPSC-derived neurons.

A: Classification of novel LncRNAs according to genomic context. B: Exon distribution of novel LncRNAs. C: Median read counts of LncRNAs (novel and ENSEMBL annotated) vs protein coding genes in human IPSC-derived neurons. Data is presented as mean plus SEM. Significance was assessed with the Mann–Whitney U test (MWW). D: Heatmap of novel and annotated intergenic LncRNAs DE between Human IPSC-derived neurons and IPSC. E, F: Expression plot of novel antisense LncRNAs (E) and annotated ENSEMBL antisense LncRNAs (F) vs the sense protein coding gene. LncRNAs antisense to DE genes Kcnj6 and Trpm3 were DE with opposite log2 fold changes to the DE sense gene. P < 0.5 *, p < 0.01 **, P < 0.001 ***.