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. Author manuscript; available in PMC: 2019 Jun 10.
Published in final edited form as: Nat Microbiol. 2018 Dec 10;4(2):293–305. doi: 10.1038/s41564-018-0306-4

Figure 5. IBD-associated changes in microbial function and their metabolic associations.

Figure 5

(A) - (E) highlight examples of metagenomically contributed enzymes that were differentially abundant in IBD, annotated by their taxonomic contributors (A - C are enriched in IBD; D and E are depleted). In each case, the enzyme was contributed by a mixture of species across the cohort, and not dominated by a single species. Each set of stacked bars represents one of the 155 PRISM metagenomes (arrayed on horizontal axes). Community enzyme abundance (log10-transformed parts per million) is represented by the top of each stack of bars; contributions from major species are linearly scaled within the total bar height. Samples are first sorted according to the dominant contributor to a function and then grouped by phenotype (sample ordering differs between panels). (F) and (G) illustrate correlations between community-total enzyme abundance and IBD-associated metabolites across 68 CD, 53 UC, and 34 non-IBD control subjects. Values plotted are raw measurements (not residuals) normalized to parts per million (PPM) units and then log10-transformed. Values <1 PPM (including 0s) were set to 1 PPM for plotting; corresponding points are shown without fill and jittered (all other points have solid fill). The given r values indicate Spearman correlation.