Skip to main content
. Author manuscript; available in PMC: 2019 May 15.
Published in final edited form as: Autophagy. 2019 Feb 20;15(5):886–899. doi: 10.1080/15548627.2019.1569912

Figure 6. Accumulation of SQSTM1 correlates with negative membrane CDH1 expression in pancreatic adenocarcinoma.

Figure 6

(A) The protein expression of SQSTM1 and mRNA level of CDH1 is significantly inversely correlated in the TCGA pancreatic adenocarcinoma Provisional dataset (Spearman’s R = -0.23, n = 98, P = 0.025). (B) Adjacent tumor sections from representative cases show SQSTM1 and CDH1 expression in human pancreatic adenocarcinoma. Scale bar: 100 μm. (C) The relationship between SQSTM1 expression and protein expression of CDH1 was analyzed by Spearman rank correlation test (R = -0.33, n = 63, P = 0.00822). (D) Diagram summarizing the role of autophagy inhibition in oncogenic RAS-induced EMT (details are provided in the Discussion).