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. Author manuscript; available in PMC: 2019 Sep 21.
Published in final edited form as: Mol Psychiatry. 2019 Jan 7;24(10):1435–1450. doi: 10.1038/s41380-018-0321-0

Figure 2. Case-control vs stratified model example with adult autism and mentalizing ability.

Figure 2

This figure reports data from Lombardo et al., (2016)24 on two independent datasets of adults with autism and performance on an advanced mentalizing test, the Reading the Mind in the Eyes Test (RMET). Panels A (Discovery) and B (Replication) show case-control differentiation and the standardized effect size for each dataset. Panels C-F shows RMET scores and standardized effect sizes from the same two datasets after unsupervised data-driven stratification into 5 distinct autism subgroups and 4 distinct TD subgroups. Autism subgroups 1-2 are highly impaired on the RMET, while autism subgroups 3-5 are completely overlapping in RMET scores with the TD population.