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. Author manuscript; available in PMC: 2019 Mar 16.
Published in final edited form as: Circ Genom Precis Med. 2019 Feb;12(2):e002413. doi: 10.1161/CIRCGEN.118.002413

Figure 3.

Figure 3

Selective blockage of the IL-6 trans-signalling pathway using sgp130 in the angiotensin II + anti-TGFβ model reduces aortic rupture. Mice were treated with sgp130-Fc or human IgG1 Fc (Hum-Fc) (n=10 mice/group) starting one week before angiotensin II and anti-TGFβ infusion. A - Plasma concentration of cytokines at day 0 (before angiotensin II and anti-TGFβ infusion) and day 7. *p<0.05 Hum-Fc vs sgp130; ***p<0.001 Hum-Fc vs sgp130; 2-way ANOVA followed by uncorrected fisher’s test. B - Plasma concentration of serum amyloid A (SAA) at day 0 (before angiotensin II and anti-TGFβ infusion) and day 7. C - Systolic blood pressure measurement using tail cuff at day 0 and day 7 after angiotensin II and anti-TGFβ infusion. D - Survival curves of mice after angiotensin II and anti-TGFβ infusion. *p<0.05 Hum-Fc vs sgp130; Gehan-Breslow-Wilcoxon test. All data for the generation of the graphs shown in Figure 3 were generated in one independent experiment.