. Author manuscript; available in PMC: 2019 Mar 16.

Published in final edited form as: Circ Genom Precis Med. 2019 Feb;12(2):e002413. doi: 10.1161/CIRCGEN.118.002413

Table 2. Comparison of results for the association between IL-6R and abdominal aortic aneurysm from human genetic analysis and mouse experimental models.

Model	Inhibition of IL-6 signalling	Effect on AAA growth/survival	p-value of effect	Other cardiovascular markers (p<0.05)
*Humans stratified for IL6R-Asp358Ala*	Minor allele associated with dampening of classical signalling. Effects on trans-signalling not clear.	Non-significant change in AAA growth (0.06mm/year)^*	0.136	Increased IL-6, sIL-6R, CXCL10, CXCL11, IL1α and CD6; Reduced MMP3, OPG, IGFBP1, TIMP4
Angiotensin II + anti-TGFβ mouse model	Both classical and trans-signalling	No difference in survival	1.000	Increased IL-6; Reduced SAA, IL-2, IL-5, CXCL1 and SBP
Angiotensin II + anti-TGFβ mouse model	Only trans-signalling	Improved survival	0.040	Increased IL-5; Reduced TNFα
Elastase + anti-TGFβ mouse model	Both classical and trans-signalling	Decreased survival	0.029	Increased recruitment of CD3⁺ T cells
Elastase + anti-TGFβ mouse model	Only trans-signalling	Improved survival	0.024	Increased collagen content of the arterial wall

Effect indicated per copy of the IL6-R minor allele.