Skip to main content
. Author manuscript; available in PMC: 2019 Apr 1.
Published in final edited form as: Blood. 2019 Jan 23;133(13):1495–1506. doi: 10.1182/blood-2018-07-866095

Figure 1. Impact of the FLT3-ITD knock-in allele on APL initiation by PML/RARA.

Figure 1

(A) Overall survival and acute leukemia-free survival of lethally irradiated recipients transplanted with P/R-FLT3ki, FLT3ki or P/R bone marrow cells. (B) Strategy to obtain P/R and P/R-FLT3ki cells in a FVB background, subsequently tagged with GFP by retroviral transduction. (C) GSEA analysis for 50 hallmark gene sets between P/R and P/R-FLT3ki mice. Transcriptomic analysis performed on RNA extracted from GFP-positive leukemic cells. Only significant pathways were represented (with False Discovery Rate q-values (FDR.q.val) < 0.05) according to NES value.