Table 12. Effect of bisphosphonate treatment on bone deformity.

Risk-benefit balance The effects of bisphosphonates on bone deformity have not been adequately studied. Quality of evidence Very low Patient values and preferences Bone deformity is of concern to patients. If treatment strategies could be identified that were effective in preventing bone deformity, it is likely that they would be favoured by patients. Costs and use of resources Bisphosphonates are inexpensive but intravenous therapy involves additional support costs and costs in terms of patient time attending for the infusion which may need to be considered. Recommendation There is insufficient evidence that bisphosphonates can prevent or treat bone deformity in PDB and they are not recommended for this indication.