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. Author manuscript; available in PMC: 2019 Nov 18.
Published in final edited form as: Cell Death Differ. 2019 Apr 15;26(12):2710–2726. doi: 10.1038/s41418-019-0330-9

Fig. 6. NEMO deletion strongly prevents biliary damage but leads to only a marginal delay in HCC progression in TAK1LPC-KO mice.

Fig. 6

(A-B) Serum levels of ALT (A) and total Bilirubin (B) in 6-, 12- and 52-week-old mice with the indicated genotypes. (C-E) Representative liver photos and images of liver sections stained for Masson’s trichrome from 12- (C), 28- (D), and 52-week-old mice (E) with the indicated genotypes. Dysplastic nodules or HCC are outlined and marked with an asterisk in D and E. (F) Histopathological evaluation of hepatocarcinogenesis in samples of liver samples from mice with the indicated age. (G) LW/BW ratio in 52-week-old mice with the indicated genotypes. The number of mice analyzed (n) is indicated in every graph. All graphs show mean values of the individual data points. *p <0.05, **p <0.01, ***p <0.005. Bars: (C-E) upper, 1 cm; lower, 100 μm.