Table 1. Summary data of bone marrow harvests for GT. Data indicate median and range.
^data available for the last consecutive 8 ADA SCID patients.
| Disease | Age at GT (years) | Weight (kg) | Harvested volume (ml) | Volume/kg | Collected TNC (x108)/kg | CD34+ (%) | Collected CD34+ cells (x106)/kg | Selected CD34+ cells (x106)/kg | Infused CD34+ cells (x106)/kg |
|---|---|---|---|---|---|---|---|---|---|
|
ADA SCID (n=23) |
1.7 (0.5-6.0) |
10.1 (5.9-26.5) |
303.0 (190.0-1167.5) |
31.2 (14.2-48.6) |
4.2 (2.9-6.8) |
5.7 (2.0-6.7)^ |
28.9 (9.8-43.1)^ |
13.8 (4.4-22.9) |
10.7 (3.7-19.7) |
|
WAS (n=6) |
2.1 (0.9-6.0) |
12.7 (8.0-26.3) |
424.3 (275.0-773.0) |
34.2 (29.4-36.5) |
5.7 (3.5-6.6) |
2.9 (1.8-5.2) |
15.8 (10.8-18.7) |
9.1 (4.5-14.5) |
9.0 (3.7-14.1) |
|
MLD (n=28) |
1.3 (0.5-11.4) |
11 (7.3-25.3) |
420.0 (194.0-1132.0) |
36.9 (17.6-56.6) |
6.3 (3.4-9.4) |
3.0 (1.0-7.7) |
16.3 (5.6-65.9) |
9.6 (3.9-34.7) |
10.3 (3.8-25.9) |
|
Total (n=57) |
1.5 (0.5-11.4) |
10.6 (5.9-26.5) |
348.0 (190.0-1167.5) |
34.2 (14.2-56.6) |
5.1 (2.9-9.4) |
3.1 (1.0-7.7) |
17.3 (5.6-65.9) |
10.4 (3.9-34.7) |
10.3 (3.7-25.9) |