Table 1. Selected examples of organ-specific metabolite production and consumption.
See also Data File 1.
| Organ | Production | Consumption | ||
|---|---|---|---|---|
| Metabolite | Log2 (V/A) | Metabolite | Log2 (V/A) | |
| Liver | Glutamate | 0.64 ± 0.11 | Bile acids (5) | -2.89 ± 0.19 |
| Triethanolamine | 0.49 ± 0.17 | Phenylpropionic acid (2) | -2.29 ± 0.12 | |
| Acetoacetate | 0.38 ± 0.09 | Short-chain fatty acids (3) | -2.02 ± 0.83 | |
| Portal (Intestine) | Bile acids (6) | 3.28 ± 0.21 | 2-Methylhippuric acid | -0.69 ± 0.15 |
| Phenylpropionic acid (2) | 2.84 ± 0.32 | Glucose | -0.31 ± 0.05 | |
| Short-chain fatty acids (3) | 2.82 ± 1.15 | Glutamine | -0.28 ± 0.02 | |
| Colon | Short-chain fatty acids (3) | 4.65 ± 1.21 | 2-Methylhippuric acid | -0.60 ± 0.21 |
| Lithocholic acid | 4.04 ± 1.10 | 5-Hydroxylysine | -0.41 ± 0.05 | |
| Phenylpropionic acid (2) | 3.42 ± 0.48 | Glucose | -0.39 ± 0.05 | |
| Pancreas | Xanthine | 1.05 ± 0.26 | 5-Hydroxylysine | -0.79 ± 0.19 |
| Capryloyl glycine | 0.51 ± 0.09 | N-Carbamoylsarcosine | -0.39 ± 0.09 | |
| TCA intermediates (5) | 0.36 ± 0.17 | Amino acids (8) | -0.36 ± 0.01 | |
| Spleen | O-Phosphorylethanolamine | 1.11 ± 0.22 | Adenosine | -0.61 ± 0.14 |
| Nucleosides (9) | 0.52 ± 0.03 | Dihydroxymandelic acid | -0.33 ± 0.07 | |
| C22, C24 very long-chain fatty acids (11) | 0.35 ± 0.008 | C5 Acylcarnitine | -0.26 ± 0.02 | |
| Head (brain) | Synephrine | 1.89 ± 0.68 | Dihydroxymandelic acid | -0.38 ± 0.12 |
| Gluconolactone, Gluconate | 1.66 ± 0.03 | 2-Methylhippuric acid | -0.34 ± 0.11 | |
| Acetate | 1.46 ± 0.39 | Glutamate | -0.30 ± 0.09 | |
| Leg (muscle) | Hypotaurine | 0.69 ± 0.12 | Glutamate | -1.41 ± 0.33 |
| Branched chain hydroxyl acids (2) | 0.65 ± 0.12 | Ketone bodies (2) | -0.58 ± 0.14 | |
| Medium and long-chain | 0.57 ± 0.02 | Short-chain | -0.36 ± 0.05 | |
| acylcarnitines (11) | acylcarnitines (5) | |||
| Lung | 2-Phenylpropionic acid | 0.48 ± 0.14 | 5-Keto-D-gluconic acid | -0.31 ± 0.07 |
| Aconitate | 0.26 ± 0.03 | Kynurenate | -0.22 ± 0.03 | |
| C22:0, C24:0 fatty acids | 0.24 ± 0.02 | 3-Hydroxyanthranilic acid | -0.17 ± 0.02 | |
| Kidney | Glycocyamine | 1.87 ± 0.12 | N-Formyl-L-methionine | -2.66 ± 0.32 |
| Serine | 0.73 ± 0.12 | Medium-chain | -2.61 ± 0.19 | |
| acylcarnitines (4) | ||||
| Allantoate | 0.53± 0.12 | N-acetyl amino acids (9) | -1.27 ± 0.87 | |
| Heart | Hypotaurine | 0.34 ± 0.11 | 3-Phenylpropionic acid | -0.71 ± 0.24 |
| Glutamate | 0.26 ± 0.04 | Unsaturated long-chain fatty acids (11) | -0.53 ± 0.06 | |
| Biotin | 0.25 ± 0.06 | Hydroxyindoleacetic acid | -0.47 ± 0.12 | |
| Ear (skin) | Guanine | 0.82 ± 0.19 | Hydroxyhippuric acid | -0.35 ± 0.08 |
| Taurine | 0.53 ± 0.08 | Indole metabolites (2) | -0.23 ± 0.02 | |
| Long-chain | 0.20 ± 0.04 | Serine | -0.15 ± 0.01 | |
| acylcarnitines (3) | ||||