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. Author manuscript; available in PMC: 2020 May 18.
Published in final edited form as: Nat Genet. 2019 Nov 18;51(12):1670–1678. doi: 10.1038/s41588-019-0512-x

Figure 3. Trans-ethnic fine-mapping improves resolution.

Figure 3

a, An association was mapped to a single variant (rs11587347) after adding EAS samples and using the trans-ancestry fine-mapping approach. Regional association plots were generated using http://locuszoom.org/ and LD from 1000 Genomes Project Phase 3 EUR subjects. b, LD with the lead variant (rs11587347). c, The lead variant (rs11587347) has strong association significance in both populations and low heterogeneity across populations. a-c, n (EAS stage 1) = 13,305 cases, 35,362 controls; n (EUR PGC2) = 33,640 cases, 43,456 controls. d, Number of variants in the 95% credible set using the trans-ancestry (EAS+EUR) and published fine-mapping approaches (EUR only).