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. Author manuscript; available in PMC: 2019 Nov 7.
Published in final edited form as: J Immunol. 2019 Oct 4;203(10):2724–2734. doi: 10.4049/jimmunol.1900640

Figure 2. Enhanced anti-helminth responses in the absence of NLRP3.

Figure 2

WT and Nlrp3−/− mice were infected with 500 N. brasiliensis (Nb) L3s and (A) lung stage L4 larvae were quantified on days 1 and 2 post-infection. (B) Adult worms in the small intestine (days 4 and 6 post-infection) and (C) fecal parasite eggs shed in the stool (day 6) were quantified (per fecal pellet). (D) Representative images of proximal small intestine from naïve and day 6 infected mice, stained with Alcian Blue/Periodic Acid-Schiff. Goblet cells were enumerated from 10 randomly selected villi per mouse. Data from A–D are representative (mean ± s.e.m.) of 3 individual experiments with 3-5 mice per group (per experiment). *P<0.05, **P<0.01 (one-way ANOVA and Tukey-Kramer post hoc test or unpaired two-tailed student’s t test).