Table 2. The SNP-based heritabilities (h2) of eight pain phenotypes from the UK Biobank cohort and their genetic correlations with depressive symptoms, major depression and neuroticism.
| Heritability | Depressive symptoms | Major depressive disorder | Neuroticism | |||||
|---|---|---|---|---|---|---|---|---|
| Pain phenotypes | h2 (SE) | P | rg | P | rg | P | rg | P |
| Headache | 0.21 (0.015) | 3.9 × 10-45 |
0.52 (0.036) |
1.6 × 10-46 |
0.39 (0.057) |
1.6 × 10-11 |
0.50 (0.028) |
2.2 × 10-72 |
| Facial pain | 0.24 (0.12) | 0.036 |
0.33 (0.091) |
2 × 10-4 |
0.34 (0.137) |
0.01 |
0.30 (0.068) |
1.0 × 10-5 |
| Neck or shoulder pain | 0.11 (0.017) | 4.3 × 10-11 |
0.55 (0.048) |
3.4 × 10-30 |
0.40 (0.073) |
5.8 × 10-8 |
0.44 (0.039) |
5.3 × 10-7 |
| Stomach or abdominal pain | 0.14 (0.050) | 0.004 |
0.67 (0.134) |
5.7 × 10-7 |
0.53 (0.15) |
5 × 10-4 |
0.70 (0.118) |
2.4 × 10-9 |
| Back pain | 0.11 (0.020) | 8.4 × 10-9 |
0.48 (0.063) |
1.5 × 10-14 |
0.36 (0.086) |
3 × 10-5 |
0.40 (0.054) |
1.7 × 10-13 |
| Hip pain | 0.12 (0.041) | 0.005 | 0.34 (0.16) |
0.03 | 0.04 (0.167) |
0.80 | 0.27 (0.128) |
0.04 |
| Knee pain | 0.08 (0.029) | 0.007 | 0.12 (0.083) |
0.13 | -0.07 (0.113) |
0.53 | 0.18 (0.057) |
0.002 |
| Pain all over body | 0.31 (0.072) | 1.3 × 10-5 |
0.69 (0.063) |
1.4 × 10-27 |
0.43 (0.095) |
5.6 × 10-6 |
0.45 (0.054) |
3.4 × 10-17 |
P values < 0.001 (0.05/24+28) were considered as significant for genetic correlations. Those significant rg values were in bold.
SE: standard error
rg: genetic correlation