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. Author manuscript; available in PMC: 2019 Oct 2.
Published in final edited form as: Brain. 2019 Oct 1;142(10):2938–2947. doi: 10.1093/brain/awz257

Table 1. Loci significantly associated with left-handedness.

Chromosome Positiona Index SNP Effect Allele EAFLb EAFRc INFOd OR (95% CI) p Candidate Genesf
2 210246064 rs13017199 G 0.368 0.361 0.997 1.04 (1.03-1.06) 3.3 × 10-8 MAP2
6* 30694374 rs3094128 C 0.211 0.220 1.000 0.95 (0.94-0.97) 2.9 × 10-8 TUBB, MICB, FLOT1
17 44857352 rs199512 C 0.791 0.782 1.000 1.06 (1.04-1.07) 4.1 × 10-9 WNT3, MAPT, MAPT-AS1
22 23412190 rs45608532 A 0.075 0.069 0.942 1.09 (1.06-1.12) 1.4 × 10-8 RTDR1, GNAZ
*

Only significant in non-right handers (i.e. left-handers + ambidextrous) vs right-handers GWAS

a

Based on NCBI Genome Build 37 (hg19).

b

The effect allele frequency in left-handers (or left-handers + ambidextrous individuals in the case of rs3094128 on chromosome 6).

c

The effect allele frequency in right-handers.

d

The SNP INFO score for imputed SNPs.

f

Based on eQTL data (Supplementary Table 3), positional gene mapping in FUMA (Supplementary Figure 2), and biological plausibility.