Table 1. Evidence about the effectiveness of adherence-enhancing interventions.

Intervention subclass	OP studies	Other conditions*	Conclusion
Education and support
Patient education program	4	4	Mixed evidence of effectiveness
Patient counselling	1	10	Strong evidence of effectiveness
Patient education combined with counselling	11	15	Strong evidence of effectiveness
Provision of educational material	2	5	No evidence of effectiveness
Monitoring supervision
Non-adherence monitoring	1	2	Limited evidence of effectiveness
Adherence monitoring combined with counselling	5	10	Strong evidence of effectiveness
Drug regimen combined with counselling	1	1	Limited evidence of effectiveness
Reminders to take the medication	1	7	Strong evidence of effectiveness
Monitoring biomarkers	3	N/a	No evidence of effectiveness
Dose regimen adjustment and simplification
Dose simplification including flexible dosing regimen	4	8	Strong evidence of effectiveness
Individual medication program	1	1	Limited evidence of effectiveness
Costs covered	N/a	1	Limited evidence of effectiveness
Other subclasses
Combination of interventions mentioned above	3	2	Mixed evidence of effectiveness
Other interventions	4	9	Low evidence of effectiveness

N/a Not Applicable

^*Restricted to depression, cardiovascular diseases and hypercholesterolaemia