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. Author manuscript; available in PMC: 2020 Jul 2.
Published in final edited form as: Leukemia. 2020 Jan 2;34(6):1613–1625. doi: 10.1038/s41375-019-0684-5

Figure 2. CD93 expression can isolate a functional stem cell population in CML.

Figure 2

(A) Analysis of the microarray, GSE47927, demonstrated a significant fold-change between CP-CML LSCs and normal HSCs in genes for cell surface proteins. The table represents the most statistically significant cell surface marker genes identified. (B) RNA from 30 BM and PB CP-CML samples was utilized to validate the gene expression of CD93. MNC and CD34+-selected (n=30) samples were compared to normal BM (n=5). (C) CD93 protein expression was assessed by flow cytometry in lin-CD34+CD38-CD90+ populations between CML (peripheral blood [n=22] and BM [n=9]) and normal BM (n=7). A statistically significant increase in percentage of CD93+ cells in CML was determined using an unpaired Student’s T test (p<0.0001). MNC; MNC, BM; BM