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. Author manuscript; available in PMC: 2020 Jan 13.
Published in final edited form as: RSC Adv. 2020 Jan 9;10(3):1776–1785. doi: 10.1039/c9ra09284f

Scheme 1. Synthesis of phosphonoacetate ADPR analogue 1.

Scheme 1

Reagents and conditions: a) NaOH, water, EtOH, 20°C (97%); b) DCC, DMAP (cat.), THF, 20 °C (82%); c) TMSBr, Pyridine, 20 °C, 16h (46%); d) DCC, Pyridine, 120 °C, 16h (57%); e) aqueous TFA 75%, 2h, 20 °C (36%).