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Solubility of a set of compound 1 analogues designed to increase aqueous solubility. Turbidity was experimentally determined by measuring absorbance at 625 nm at 250 μM and values are relative to DMSO. All turbidity values are the mean of three independent experiments ± standard deviation.
| Compound | Structure | Turbidity |
|---|---|---|
| 1 |  |
4.57 ± 0.76 |
| 6 |  |
1.01 ± 0.03 |
| 7 |  |
6.52 ± 0.95 |
| 8 |  |
6.11 ± 1.61 |
| 9 |  |
1.04 ± 0.04 |
