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. Author manuscript; available in PMC: 2020 Aug 14.
Published in final edited form as: Science. 2020 Jan 30;367(6479):806–810. doi: 10.1126/science.aay4919

Fig. 3. Effects of Q148H/G140S substitutions on DTG and analogue 1 activities.

Fig. 3

(A) Structure of analogue 1 (top; colors as in Fig. 2A) and a time course of 3H-DTG and analogue 1 dissociation from wild type and Q148H/G140S HIV-1 intasomes (bottom). Results from three independent experiments are plotted; each data point is an average of two measurements done in parallel; trendlines are for illustration purpose. Apparent INSTI dissociative half-times from the mutant intasome are indicated. (B) Activities of DTG and analogue 1 against wild type (top) and Q148H/G140S (bottom) HIV-1. Results are averages and standard deviations of two independent experiments, with each experiment conducted in triplicate.