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. Author manuscript; available in PMC: 2019 Jul 25.
Published in final edited form as: J Physiol. 2019 Jun 2;597(13):3473–3502. doi: 10.1113/JP277726

Figure 9. Differential enhancement of LTD and LTP by spine ER is a general consequence of ICCR kinetics.

Figure 9

A, left, change in maximum CaM activation due to the presence of ER as a function of the spine NMDAR conductance and induction frequency; right, dependence of the modified plasticity (change in Δw) due to presence of ER on the NMDAR conductance and induction frequency. B and C, parameter sensitivity in the case of STDP inputs for the triplet (B) and doublet (C) spike pairing stimuli. (All results for comparison between ER− control spine and an equivalent ER+ spine with 30 IP3Rs; plasticity thresholds appropriately adjusted to give (in the ER− spine) fD = 1 Hz and fP = 15 Hz for rate-dependent plasticity, and, separately, STDP for −35 ms < Δt < 70 ms.) [Colour figure can be viewed at wileyonlinelibrary.com]