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. Author manuscript; available in PMC: 2020 Jun 1.
Published in final edited form as: Cortex. 2020 Feb 18;127:29–41. doi: 10.1016/j.cortex.2020.02.002

Figure 1. Increased prefrontal activity in alien hand.

Figure 1

A) In a patient with the neurodegenerative corticobasal syndrome, unwanted movement of an alien limb was specifically associated with activity in the inferior frontal gyrus (top) and increased activity of the primary motor cortex. Adapted from Schaefer et al. (2010). B) In a group of patients with the neurodegenerative corticobasal syndrome, reduced sense of agency and alien limb severity were associated with structural and functional changes in the pre-SMA and its connectivity with a large prefrontal network. From Wolpe et al. (2014).