Table 4. Adjusted associations between maternal mid-gestation FPG and neonatal abdominal adiposity stratified by placental inositol tertiles.
| FPG (mmol/L) | sSAT (ml) | dSAT (ml) | IAT (ml) | TAAT (ml) | |||||
|---|---|---|---|---|---|---|---|---|---|
|
| |||||||||
| P for interaction* | 0.021 | 0.015 | 0.016 | 0.004 | |||||
|
| |||||||||
| Tertiles of inositol | Inositol z-score, range | β§
(95% CI) |
P value | β§
(95% CI) |
P value | β§
(95% CI) |
P value | β§
(95% CI) |
P value |
| All in MRI subset | |||||||||
|
| |||||||||
| Lowest (n=80 ‖ ) | -3.337, -0.473 |
12.0 (6.2, 17.8) |
<0.001 | 3.5 (1.8, 5.3) |
<0.001 | 5.4 (3.5, 7.4) |
<0.001 | 21.0 (13.1, 28.8) |
<0.001 |
| Middle (n=65 ‖ ) | -0.469, 0.336 |
12.1 (5.7, 18.5) |
0.004 | 3.3 (1.1, 5.5) |
0.002 | 4.3 (1.4, 7.5) |
0.009 | 19.7 (9.7, 29.7) |
<0.001 |
| Highest (n=74 ‖ ) | 0.342, 3.610 |
1.6 (-4.9, 8.0) |
0.625 | -0.3 (-2.6, 2.0) |
0.805 | -0.5 (-3.8, 2.9) |
0.770 | 0.8 (-8.4, 10.0) |
0.862 |
|
| |||||||||
| Cases of normoglycaemia with valid MRI data # | |||||||||
|
| |||||||||
| Lowest (n=64 ‖ ) | -3.337, -0.473 |
12.5 (4.6, 20.4) |
0.003 | 3.2 (0.6, 5.8) |
0.016 | 5.6 (2.5, 8.6) |
0.001 | 21.3 (10.2, 32.3) |
<0.001 |
| Middle (n=52 ‖ ) | -0.469, 0.336 |
5.7 (-5.5, 16.9) |
0.307 | 0 (-3.9, 3.9) |
0.997 | -2.1 (-6.8, 2.6) |
0.378 | 3.7 (-13.3, 20.6) |
0.666 |
| Highest (n=66 ‖ ) | 0.342, 3.610 |
-1.7 (-9.9, 6.5) |
0.685 | -1.4 (-4.4, 1.6) |
0.340 | -2 (-6.4, 2.4) |
0.378 | -5.0 (-16.8, 6.7) |
0.394 |
Adjusted for maternal age, ethnicity, parity, pre-pregnancy BMI, tobacco smoke exposure, gestational age, neonatal sex, birthweight, and age on MRI day.
*
Interaction between placental inositol tertiles and FPG on neonatal abdominal adiposity with adjustment for covariates among all in the MRI subset.
§
Beta (β) represents the change in ml per mmol/L increase in FPG.
‖
Only cases with full data sets available are presented.
#
Defined as those with normal oral glucose tolerance test by the WHO 1999 criteria.
dSAT, deep subcutaneous adipose tissue; FPG, fasting plasma glucose; IAT, internal adipose tissue; sSAT, superficial subcutaneous adipose tissue; TAAT, total abdominal adipose tissue (sum of sSAT, dSAT and IAT).