Skip to main content
. Author manuscript; available in PMC: 2020 Oct 7.
Published in final edited form as: Mol Cell. 2020 Aug 26;80(1):102–113.e6. doi: 10.1016/j.molcel.2020.08.003

Figure 6. Model of SPRTN’s DNA Structure-Specific Protease Activity.

Figure 6

(A) Model of replication-coupled transfer of DPCs from dsDNA into a ss/dsDNA junction. The ss/dsDNA junction bears both features required for SPRTN activation: dsDNA, which is recognized by the BR, and unpaired DNA bases, which engage the ZBD.

(B) Schematic overview of the DNA structures activating SPRTN. DNA nicks, gaps, ends, bubbles, and junctions contain both features required for SPRTN activation: dsDNA and unpaired DNA bases.