Table 1.
Baseline characteristics of the OXVASC cohort stratified according to the presence of any symptomatic or asymptomatic 50-99% intracranial stenosis.
| Characteristic | Patients with intracranial vascular imaging* (N= 1368) | p-value | |
|---|---|---|---|
| Intracranial stenosis (N= 241)¶ | No intracranial stenosis (N= 1108) | ||
| Mean age (SD) | 76.0 (11.9) | 67.7 (13.8) | <0.0001 |
| Male sex (%) | 127 (52.7) | 558 (50.4) | 0.40 |
| Female sex (%) | 114 (47.3) | 550 (69.6) | |
| Caucasian (%) | 229 (95.0) | 1045 (94.3) | 0.56 |
| Hypertension (%) | 168 (69.7) | 572 (51.6) | <0.0001 |
| Diabetes mellitus (%) | 42 (17.4) | 134 (12.1) | <0.0001 |
| Hyperlipidaemia (%) | 103 (42.7) | 355 (32.0) | <0.0001 |
| Current smoker (%) | 26 (10.8) | 165 (14.9) | 0.090 |
| Atrial fibrillation (%) | 52 (21.6) | 145 (13.1) | 0.0010 |
| Any vascular disease§ (%) | 105 (43.6) | 259 (23.4) | <0.0001 |
| History of stroke or TIA (%) | 58 (24.1) | 143 (12.9) | <0.0001 |
| PVD (%) | 24 (10.0) | 36 (3.2) | <0.0001 |
| IHD (%) | 54 (22.4) | 120 (10.8) | <0.0001 |
| Event type | |||
| TIA (%) | 146 (60.6) | 735 (66.3) | 0.22 |
| Minor stroke (%) | 95 (39.4) | 373 (33.7) | |
| TOAST classification | |||
| Cardioembolic (%) | 35 (14.5) | 172 (15.5) | |
| Atherosclerotic (%) | 95 (39.4) | 78 (7.0) | |
| Undetermined (%) | 47 (19.5) | 494 (44.6) | <0.0001 |
| Lacunar (%) | 11 (4.6) | 120 (10.8) | |
| Multiple/unknown/other (%) | 53 (22.0) | 244 (22.1) | |
| Vascular territory | |||
| Carotid (%) | 129 (53.5) | 580 (52.4) | 0.12 |
| Vertebrobasilar (%) | 94 (39.0) | 408 (36.8) | |
| Uncertain/ both (%) | 18 (7.5) | 120 (10.8) | |
| Imaging modality | |||
| MRA | 188 (78.0) | 829 (74.8) | 0.039 |
| CTA | 49 (20.3) | 202 (18.2) | |
| TCD | 4 (1.7) | 77 (7.0) | |
PVD= peripheral vascular disease, IHD= ischaemic heart disease, MRA= magnetic resonance angiography, CTA= computed tomography angiography, TCD= transcranial Doppler.
*
Including: MRA, CTA or TCD.
¶
Excluding patients with intracranial vessel occlusion (n=19).
§
Vascular disease= ischaemic stroke/ TIA, PVD or IHD.