Figure 3. Fibrotic nodules in Coats’ disease on (A) optical coherence tomography, OCT from a 4-year-old-boy, and (B) low and (C-D) high power light micrographs from an enucleated biorepository eye.

The horizontal white dotted line in the inset photograph corresponds to the OCT line scan while the black dotted boxes on the low power micrograph denote the areas above and within the cholesterol granuloma shown in the high-power micrographs. A hyperreflective tubule with a hyporeflective core (green arrow) overlying exudates (yellow arrow) and a fibrotic nodule (red arrows) with subretinal fluid (blue arrow) is observed on OCT. These appear to correspond to intraretinal rosettes (green arrows) in disorganized retina overlying the cholesterol granuloma on high power light micrograph. Other notable findings on light micrograph include a fibrous capsule surrounding the cholesterol granuloma (black arrowheads), as well as multinucleated giant cells with pigment granules (black arrows) surrounding cholesterol clefts (yellow arrowheads), proliferating capillaries (red arrowheads) and fibrinous material (red arrows) within the cholesterol granuloma.