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. Author manuscript; available in PMC: 2019 Oct 2.
Published in final edited form as: Cold Spring Harb Perspect Med. 2019 Oct 1;9(10):a033506. doi: 10.1101/cshperspect.a033506

Figure 1.

Figure 1.

Phylogeny of the TMC and TMEM16 families. (A) An unrooted phylogeny tree of the TMC and TMEM16 families, derived from an alignment of vertebrate TMCs and mammalian TMEM16s. Only Nectria and human orthologs are shown here. Within the TMC branch, TMC1–3 cluster in a distinct subfamily. (B) The TMC/TMEM16 superfamily. (Panel B based on data in Medrano-Soto et al. 2018.)