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. Author manuscript; available in PMC: 2019 Oct 2.
Published in final edited form as: Cold Spring Harb Perspect Med. 2019 Oct 1;9(10):a033506. doi: 10.1101/cshperspect.a033506

Figure 2.

Figure 2.

Possible schematic of the hair cell mechano-transduction apparatus. (A) Reported interactions among six proteins essential for mechanosensory transduction in hair cells. (B) A possible arrangement of proteins within the transduction apparatus. TMC1 and PCDH15 are both dimers, so it is attractive to suppose that there is a one-to-one relationship between them, with one PCDH15 opening the pore in one TMC subunit of the dimeric channel. In addition, PCDH15 and LHFPL5 can form a tetrameric complex (Ge et al. 2018) so LHFPL5 may also be near the dimer interface, rather than as depicted. There is little information about stoichiometries for the other proteins of the complex, nor is it known which are part of a mature complex and which are only necessary for assembly.